Malonamide derivatives

US7375099B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Guido Galley · Rheinfelden (Baden), DE
• Annick Goergler · Basel, CH
• Helmut Jacobsen · Schopfheim, DE
• Eric A. Kitas · Aesch, CH
• Jens-Uwe Peters · Weil am Rhein, DE

Key dates

• Filing date: Jan 29, 2004
• Grant date: May 20, 2008
• Expiry date: Mar 12, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to malonamide derivatives of formulawherein each of the variables are as defined in the specification and to pharmaceutically acceptable acid addition salts thereof. The compounds are γ-secretase inhibitors. Thus, the invention also relates to pharmaceutical compositions containing these compounds and to a method of treating Alzheimer's disease by administering the compounds of the invention.