Copper-catalysed ligation of azides and acetylenes

US7375234B2 · kind B2 · utility

Assignee

• THE SCRIPPS RESEARCH INSTITUTE · US

Inventors

• K. Barry Sharpless · Brookline, US
• Valery Fokin · Oceanside, US
• Vsevold A. Rostovtsev · Wilmington, US
• Luke Green · Basel, CH
• Fahmi Himo · Solna, SE

Key dates

• Filing date: May 30, 2003
• Grant date: May 20, 2008
• Expiry date: Sep 30, 2023

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B01J2531/96
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A metal catalyzed click chemistry ligation process is employed to bind azides and terminal acetylenes to give triazoles. In many instances, the reaction sequence regiospecifically ligates azides and terminal acetylenes to give only 1,4-disubstituted [1,2,3]-triazoles.