Multiplex data collection and analysis in bioanalyte detection

US7410763B2 · kind B2 · utility

Assignee

• Intel Corporation · US

Inventors

• Xing Su · Cupertino, US
• Lei Sun · Santa Clara, US
• Mineo Yamakawa · Campbell, US
• Jingwu Zhang · San Jose, US
• Qing Ma · Saratoga, US
• Tae-Woong Koo · Cupertino, US
• Richard Jones · San Mateo, US

Key dates

• Filing date: Sep 1, 2005
• Grant date: Aug 12, 2008
• Expiry date: Oct 26, 2025

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/5438
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Method and device to collect multiplex data simultaneously in analyte detection and analyze the data by experimentally trained software (machine-learning) is disclosed. Various ways (magnetic particles and microcoils) are disclosed to collect multiple reporter (tag) signals. Multiplex detection can increase the biomolecule analysis efficiency by using small sample size and saving assay reagents and time. Machine learning and data analysis schemes are also disclosed. Multiple affinity binding partners, each labeled by a unique reporter, are contacted with a sample and a green spectrum is taken to detect multiple reporter signals. The spectrum is deconvoluted by experimentally trained software to identify multiple analytes.