Antihelminthic drugs as a treatment for hyperproliferative diseases
US7423015B1 · kind B1 · utility
1Cited by
15References
57Claims
0Family size
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Key dates
| Filing date | Jan 9, 2002 |
| Grant date | Sep 9, 2008 |
| Priority date | — |
| Expiry date | Aug 10, 2024 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to the use of benzimidazole derivatives for the treatment of tumors and in combination with tumor suppressor gene therapy. In a particular embodiment, treatment of p53-positive tumors with benzimidazole derivatives induces p53 expression and increases its half-life, resulting in apoptotic death of the tumor cells. Similarly, in conjunction with p53 gene therapy, benzimidazole derivatives induce p53 expression and accumulation in tumor cells regardless of their p53 status. The combination treatment subsequently elicits apoptosis of the tumor cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.