Triazine derivatives as universal peptide isotope tag reagents (U-PIT)
US7425451B2 · kind B2 · utility
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3References
27Claims
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Key dates
| Filing date | Dec 13, 2002 |
| Grant date | Sep 16, 2008 |
| Priority date | — |
| Expiry date | Aug 5, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D401/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds, compositions, methods for sequencing proteins and peptides, and methods for identifying proteins and peptides in a mixture, are disclosed. Compounds of formula A-B-C wherein A is a nucleophilic reactive group, B is a detectable moiety capable of being isotopically labeled, and C is a charge replacement group, are used to label the peptides at the N-terminus or the C-terminus. The tagged peptides can then be analyzed by mass spectroscopy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.