Screening assay to identify modulators of the sleep/wake cycle
US7427489B1 · kind B1 · utility
1Cited by
3References
33Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Jun 17, 2003 |
| Grant date | Sep 23, 2008 |
| Priority date | — |
| Expiry date | Jun 17, 2023 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Screening assays for identifying agents that modulate BK channel activity and further modulate the sleep/wake cycle in a subject, circadian regulated locomotor activity in a subject, or both are provided, as are agents identified using such screening assays. Also provided are methods of modulating the sleep/wake cycle in a subject and methods of modulating circadian regulated locomotor activity in a subject by administering an agent that modulates BK channel activity to the subject, for example, an agent identified by a screening assay as disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.