Variants of vascular endothelial cell growth factor, their uses, and processes for their production
US7427596B2 · kind B2 · utility
9Cited by
16References
19Claims
0Family size
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Key dates
| Filing date | Jun 3, 2005 |
| Grant date | Sep 23, 2008 |
| Priority date | — |
| Expiry date | Nov 29, 2025 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention involves the preparation of vascular endothelial growth factor (VEGF) variants which provide materials that are selective in respect of binding characteristics to the kinase domain region and the FMS-like tyrosine-kinase region, respectively KDR and FLT-1. The respective KDR and FLT-1 receptors are bound by corresponding domains within the VEGF compound domains. The variants hereof define those two binding regions and modify them so as to introduce changes that interrupt the binding to the respective domain. In this fashion the final biological characteristics of the VEGF molecule are selectively modified.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.