Process for preparing rapamycin 42-esters and FK-506 32-esters with dicarboxylic acid, precursors for rapamycin conjugates and antibodies
US7445916B2 · kind B2 · utility
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44References
12Claims
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Key dates
| Filing date | Apr 12, 2005 |
| Grant date | Nov 4, 2008 |
| Priority date | — |
| Expiry date | Dec 22, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P17/188
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Methods for the synthesis of regiospecific rapamycin 42-hemiesters and regiospecific FK506 32-esters with dicarboxylic acids is described. The methods involve catalyzing the reaction between a rapamycin or a FK-506 and a dicarboxylic anhydride or a bifunctional activated ester of dicarboxylic acid with a lipase.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.