Humanized antibody

US7456260B2 · kind B2 · utility

Assignees

• The United States of America as Represented by the Secretary of the Department of Health and Human Services · US
• UNIVERSITY OF READING · GB

Inventors

• Susanna Rybak · Green Cove Springs, US
• Juergen Krauss · Essen, DE
• Michaela Arndt · Mannheim, DE
• Andrew Martin · Savannah, US

Key dates

• Filing date: Jun 17, 2003
• Grant date: Nov 25, 2008
• Expiry date: Jul 17, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The current invention provides new human variable chain framework regions and humanized antibodies comprising the framework regions. The invention also provides a new method of identifying framework acceptor regions in framework sequences for backmutation to graft a donor sequence to the human framework.