ANKTM1, a cold-activated TRP-like channel expressed in nociceptive neurons
US7465581B2 · kind B2 · utility
10Cited by
0References
7Claims
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Key dates
| Filing date | Dec 17, 2003 |
| Grant date | Dec 16, 2008 |
| Priority date | — |
| Expiry date | Aug 13, 2024 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01K2227/10
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The methods and compositions of the invention are based on a method for measuring nociceptive responses in vertebrates, including humans and other mammals utilizing a newly discovered thermoreceptor belonging to the Transient Receptor Potential (TRP) family of non-selective cation channels that participates in thermosensation and pain. This receptor, designated ANKTMI, is associated with nociceptive pain, such as hyperalgesia. Accordingly, the invention provides isolated polypeptides and polynucleotides associated with nociception as well as methods for identifying or screening agents that modulate nociception.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.