Compositions and methods related to TIM-3, a Th1-specific cell surface molecule

US7470428B2 · kind B2 · utility

Assignees

• The Brigham and Women's Hospital, Inc. · US
• DANA-FARBER CANCER INSTITUTE, INC. · US

Inventors

• Vijay K. Kuchroo · Newton, US
• Laurent Monney · Bulle, CH
• Jason L. Gaglia · Boston, US
• Edward A. Greenfield · Stoughton, US
• Gordon J. Freeman · Brookline, US
• Hanspeter Waldner · Cambridge, US

Key dates

• Filing date: Jan 30, 2003
• Grant date: Dec 30, 2008
• Expiry date: Jan 30, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/50
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides compositions and methods useful for promoting or reducing T-cell trafficking to a target tissue. Also provided are compositions and methods useful for promoting or inhibiting antigen-presenting cell (APC) activation. The invention is related to discovery of functional characteristics of TIM-3, a molecule that is preferentially expressed on the surface of Th1 cells. The methods are useful for treating disorders including cancer, infectious disease, allergy, asthma, and autoimmune disease.