Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides
US7470674B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 7, 2005 |
| Grant date | Dec 30, 2008 |
| Priority date | — |
| Expiry date | Nov 14, 2026 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/55561
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides an immunostimulatory oligonucleotides for use in methods for generating an immune response or for treating a patient in need of immunostimulation. The immunostimulatory oligonucleotides of the invention preferably comprise novel purines. The immunostimulatory oligonucleotides according to the invention further comprise at least two oligonucleotides linked at their 3′ ends, internucleoside linkages or functionalized nucleobase or sugar to a non-nucleotidic linker, at least one of the oligonucleotides being an immunostimulatory oligonucleotide and having an accessible 5′ end.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.