Tryptophanyl-tRNA synthetase-derived polypeptides useful for the regulation of angiogenesis
US7476651B2 · kind B2 · utility
90Cited by
1References
17Claims
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Key dates
| Filing date | Sep 20, 2007 |
| Grant date | Jan 13, 2009 |
| Priority date | — |
| Expiry date | Sep 20, 2027 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/975
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides a method for inhibiting ocular neovascularization in a patient. The method comprises administering to a patient an ocular neovascularization inhibiting amount of a water-soluble polypeptide selected from the group consisting of SEQ ID NO: 12, SEQ ID NO: 7, and an ocular neovascularization inhibiting fragment thereof, which includes at least one of amino acid residue signature sequences HVGH (SEQ ID NO:10) and KMSAS (SEQ ID NO:11). A method for assaying the angiogenesis inhibiting activity of a composition is also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.