Method of inhibition of vascular development using an antibody
US7485297B2 · kind B2 · utility
24Cited by
12References
30Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 9, 2005 |
| Grant date | Feb 3, 2009 |
| Priority date | — |
| Expiry date | Jan 15, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Tie1 and Tie2 are receptor tyrosine kinase proteins that include a transmembrane domain. Tie1 and Tie2 are present on endothelial cells. This disclosure describes agents, such as antibodies, that bind to Tie1, Tie2, and Ang, including ones that inhibit endothelial cell activity and angiogenesis. The agents can be used to treat angiogenesis-associated disorders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.