Thiazole compounds useful as inhibitors of protein kinase

US7488727B2 · kind B2 · utility

Assignee

• Vertex Pharmaceuticals Incorporated · US

Inventors

• John Cochran · North Andover, US
• Suganthini S. Nanthakumar · Newton, US
• Edmund Harrington · Plymouth, US
• Jian Wang · Newton, US

Key dates

• Filing date: Jun 15, 2007
• Grant date: Feb 10, 2009
• Expiry date: Jun 15, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/6561
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a compound of formula I:or a pharmaceutically acceptable derivative thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK3, Aurora2, and Syk mammalian protein kinases. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of various protein kinase mediated disorders.