Chk-, Pdk- and Akt-inhibitory pyrimidines, their production and use as pharmaceutical agents

US7504410B2 · kind B2 · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Judi Bryant · Mill Valley, US
• Monica J. Kochanny · San Rafael, US
• Shendong Yuan · San Ramon, US
• Seock-Kyu Khim · Hercules, US
• Brad O. Buckman · Oakland, US
• Damian O. Arnaiz · Hercules, US
• Ulf Bömer · Glienicke, DE
• Hans Briem · Bremen, DE
• Peter Esperling · Berlin, DE
• Christoph Huwe · Berlin, DE
• Joachim Kuhnke · Leverkusen, DE
• Martina Schäfer · Berlin, DE
• Lars Wortmann · Berlin, DE
• Dirk Kosemund · Berlin, DE
• Emil Eckle · Kuchen, DE
• Richard Feldman · Corona, US
• Gary Phillips · Issaquah, US

Key dates

• Filing date: Nov 28, 2003
• Grant date: Mar 17, 2009
• Expiry date: Apr 17, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to pyrimidine derivatives of general formula (I) as inhibitors of kinases, their production as well as their use as medications for treating various diseases.