Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and their use

US7504421B2 · kind B2 · utility

Inventors

• Ulrich Rosentreter · Binnen, DE
• Rolf Henning · Wuppertal, DE
• Marcus Bauser · Berlin, DE
• Thomas Kramer · Wuppertal, DE
• Andrea Vaupel · Riehen, CH
• Walter Hubsch · Wuppertal, DE
• Klaus Dembowsky · Boston, US
• Olga Salcher-Schraufstatter · Wuppertal, DE
• Johannes-Peter Stasch · Wuppertal, DE
• Thomas Krahn · Hagen, DE
• Elisabeth Perzborn · Wuppertal, DE

Key dates

• Filing date: Feb 21, 2006
• Grant date: Mar 17, 2009
• Expiry date: Feb 21, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to compounds of general formula (I), a method for the production thereof and the use thereof as pharmacologically effective substances for a broad medical indication spectrum. Furthermore, selective adenosine receptor ligands, preferably selective adenosine A1-, adenosine A2a- and/or adenosine A2b-receptor ligands are provided for the prophylaxis and/or the treatment of diseases, especially cardiovascular diseases, diseases of the urogenital region, diseases of the respiratory tract, inflammatory and neuroinflammatory diseases, diabetes, especially pancreatic diabetes, neurodegenerative diseases, pain states, cancer as well as liver fibrosis and liver cirrhosis.