Pyrrolobenzodiazepine derivatives, compositions comprising the same and methods related thereto

US7511032B2 · kind B2 · utility

Assignees

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US
• STARKS ASSOCIATES INC. · US
• Midwest Research Institute, Inc. · US
• SPIROGEN LIMITED · GB

Inventors

• Paul S. Liu · Bethesda, US
• B. Rao Vishnuvajjala · Rockville, US
• Kenneth M. Snader · Germantown, US
• David E. Thurston · Fareham, GB
• Philip Wilson Howard · London, GB
• Luke Y. Hsiao · San Diego, US
• Gregory Turner · Independence, US

Key dates

• Filing date: Oct 22, 2004
• Grant date: Mar 31, 2009
• Expiry date: Feb 23, 2025

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds of Formula (I) wherein X, Y, Ri-R7, T1, T2, Z, and p are as described herein; a pharmaceutical composition comprising a compound of Formula (I) and a carrier; a method of inhibiting growth of a cell, which method comprises administering in an amount effective to inhibit growth a compound of Formula (I); a method of treating cancer in a mammal, which method comprises administering in an amount effective to treat cancer a compound of Formula (I); a method of treating a viral, parasitic, or bacterial infection of a cell, which method comprises administering in an amount effective to treat a viral, parasitic, or bacterial infection a compound of Formula (I); and a method of preparing a compound of Formula (I) as described herein.