Suppressors of CpG oligonucleotides and methods of use

US7514414B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Dennis Klinman · Potomac, US
• Rainald Zeuner · Kiel, DE
• Mayda Gursel · Ankara, TR
• Ihsan Gursel · Rockville, US
• Daniela Verthelyi · Potomac, US

Key dates

• Filing date: Sep 24, 2002
• Grant date: Apr 7, 2009
• Expiry date: Oct 25, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/3515
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating an immune-mediated disorder, such as, but not limited to, an autoimmune disease, by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide. Also disclosed are methods of suppressing an immune response in a subject by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide.