Patent · US Active

2-amino-3,4-dihydro-pyrido[3,4-d]pyrimidine derivatives useful as inhibitors of β-secretase (BACE)

US7531545B2 · kind B2 · utility

7Cited by

2References

14Claims

0Family size

Assignee

Janssen Pharmaceutica NA · BE

Inventors

Ellen Baxter · Glenside, US
Christopher J. Creighton · San Diego, US
Yifang Huang · Cheltenham, US
Chi Luo · Lansdale, US
Michael H. Parker · Doylestown, US
Allen B. Reitz · Lansdale, US
Charles H. Reynolds · Austin, US
Tina Morgan Ross · Limerick, US
Eric Strobel · Hatboro, US
Brett A. Tounge · Blue Bell, US

Key dates

Filing date	Oct 25, 2006
Grant date	May 12, 2009
Priority date	—
Expiry date	Oct 25, 2026

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D471/04
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention is directed to novel 2-amino-3,4-dihydro-pyrido[3,4-d]pyrimidine derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of β-secretase, also known as β-site cleaving enzyme and BACE, BACE1, Asp2 and memapsin2.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.