Quinoline derivatives as H3R inverse agonists

US7534891B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Silvia Gatti McArthur · Basel, CH
• Cornelia Hertel · Münchenstein, CH
• Matthias Nettekoven · Weil am Rhein, DE
• Susanne Raab · Echterdingen, DE
• Hans Richter · Weil am Rhein, DE
• Olivier Roche · Folgensbourg, FR
• Rosa Maria Rodriguez-Sarmiento · Basel, CH
• Franz Schuler · Riehen, CH

Key dates

• Filing date: Oct 14, 2005
• Grant date: May 19, 2009
• Expiry date: Jun 13, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of formula I:and pharmaceutically acceptable salts thereof as well as to pharmaceutical compositions comprising these compounds and to methods for their preparation. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.