Piperidine-substituted indoles-or heteroderivatives thereof

US7544806B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Ralf Anderskewitz · Laupheim, DE
• Franz Birke · Ingelheim am Rhein, DE
• Thierry Bouyssou · Mietingen, DE
• Horst Dollinger · Schemmerhofen, DE
• Domnic Martyres · Biberach, DE
• Pascale Pouzet · Biberach, DE

Key dates

• Filing date: Nov 16, 2004
• Grant date: Jun 9, 2009
• Expiry date: Feb 28, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Accordingly, one object of the present invention are novel piperidine-substituted indoles- or heteroderivatives thereof of the formula 1:wherein R1, R5, R6, A, B, D-E, X-W-V, Y, i, j, n and m are defined as below.Another object of the present invention is to provide agonists or antagonists of CCR-3, or pharmaceutically acceptable salts thereof, more particularly to provide pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt thereof.