Mutants of deoxycytidine kinase having extended enzymatic activity
US7547513B2 · kind B2 · utility
1Cited by
7References
12Claims
0Family size
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Key dates
| Filing date | May 19, 2005 |
| Grant date | Jun 16, 2009 |
| Priority date | — |
| Expiry date | May 7, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/1058
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention relates to a method for artificial in vivo evolution of proteins, said method making it possible to bring about the evolution of a protein X by complementation of a relative protein Y, X and Y both belonging to the same class of enzyme commission (EC) nomenclature or belonging to related classes. The mutants D133E and R104Q of desoxycytidine kinase (DCK) were obtained; both of said mutations result in acquisition of thymidine kinase activity by DCK.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.