5′-modified bicyclic nucleic acid analogs
US7547684B2 · kind B2 · utility
283Cited by
123References
50Claims
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Key dates
| Filing date | May 10, 2007 |
| Grant date | Jun 16, 2009 |
| Priority date | — |
| Expiry date | Oct 28, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H21/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides 5′-modified bicyclic nucleoside analogs and oligomeric compounds comprising at least one of these nucleoside analogs. In preferred embodiments the nucleoside analogs have either (R) or (S)-chirality at the 5′-carbon. These bicyclic nucleoside analogs are useful for enhancing properties of oligomeric compounds including for example enhanced nuclease resistance.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.