Variants and chemically-modified variants of phenylalanine ammonia-lyase
US7553653B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Sep 19, 2005 |
| Grant date | Jun 30, 2009 |
| Priority date | — |
| Expiry date | Nov 17, 2026 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A90/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention pertains to the use of the protein phenylalanine ammonia-lyase, as well as the biologically-active derivatives of the said protein for preventing or treating diseases associated with a phenylalanine imbalance in a human or animal body. More particularly, the present invention relates to the therapeutic use of the above-cited molecules for preventing or treating a phenylalanine imbalance in vivo. This invention also deals with therapeutic compositions comprising a pharmaceutically active amount of the above-described therapeutic molecules as well as with therapeutic methods using the said therapeutic compositions. Finally, the present invention relates to processes for selecting more therapeutically-effective variants of said protein as well as to the selected variants themselves.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.