Compositions for the delivery of negatively charged molecules

US7553830B2 · kind B2 · utility

Assignee

• Sirna Therapeutics, Inc. · US

Inventors

• Leonid Beigelman · San Mateo, US
• Jasenka Matulic-Adamic · Boulder, US
• Alexander Karpeisky · Aurora, US
• Peter Haeberli · Berthoud, US
• David Sweedler · Louisville, US
• Mark Reynolds · Stamford, US
• Nilabh Chaudhary · Diemelstraße, US
• John Min · Longmont, US

Key dates

• Filing date: Apr 14, 2005
• Grant date: Jun 30, 2009
• Expiry date: Aug 15, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N15/88
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention features permeability enhancer molecules, and methods, to increase membrane permeability of various molecules, such as nucleic acids, polynucleotides, oligonucleotides, enzymatic nucleic acid molecules, antisense nucleic acid molecules, 2-5A antisense chimeras, triplex forming oligonucleotides, decoy RNAS, dsRNAs, siRNAs, aptamers, or antisense nucleic acids containing nucleic acid cleaving chemical groups, peptides, polypeptides, proteins, carbohydrates, steroids, metals and small molecules, thereby facilitating cellular uptake of such molecules.