Multi-domain amphipathic helical peptides and methods of their use

US7572771B1 · kind B1 · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Alan T. Remaley · Bethesda, US
• Stephen J. Demosky · Gaithersburg, US
• John A. Stonik · Gaithersburg, US
• Marcele J. A. Amar · Gaithersburg, US
• Edward B. Neufeld · Washington, US
• H. Bryan Brewer · Potomac, US
• Fairwell Thomas · Rockville, US

Key dates

• Filing date: Oct 14, 2005
• Grant date: Aug 11, 2009
• Expiry date: Oct 14, 2025

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are peptides or peptide analogs with multiple amphipathic α-helical domains that promote lipid efflux from cells via an ABCA1-dependent pathway. Also provided herein are methods of using multi-domain amphipathic α-helical peptides or peptide analogs to treat or inhibit dyslipidemic disorders. Methods for identifying non-cytotoxic peptides that promote ABCA1-dependent lipid efflux from cells are also disclosed herein.