Identification of anti-HIV compounds inhibiting virus assembly and binding of nucleocapsid protein to nucleic acid

US7572828B2 · kind B2 · utility

Assignee

• The United States of America as Represented by the Secretary of the Department of Health and Human Services · US

Inventors

• Robert H. Shoemaker · Royal Oak, US
• Michael Currens · Frederick, US
• Alan Rein · Takoma Park, US
• Robert A. Fisher · Mesa, US
• Andrew Stephen · Catonsville, US
• Karen Worthy · Germantown, US
• Shizuko Sei · Bethesda, US
• Bruce Crise · Frederick, US
• Louis E. Henderson · Mount Airy, US
• Ya-Xiong Feng · Bethesda, US

Key dates

• Filing date: Oct 8, 2003
• Grant date: Aug 11, 2009
• Expiry date: Aug 6, 2024

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/68
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides methods and pharmaceutical compositions for inhibiting viral replication, particularly retroviral replication. The methods comprise administration of stibonic acid or diphenyl compounds that disrupt viral nucleocapsid binding to nucleic acids.