Fused heterocyclic compounds and their use as metabotropic glutamate receptor antagonists

US7576077B2 · kind B2 · utility

Assignee

• ASTRAZENECA AB · SE

Inventors

• David Wensbo · Malung, SE
• Martin Johansson · Helsingborg, SE
• Alexander Minidis · Malung, SE
• Karin Staaf · Malung, SE
• Annika Kers · Malung, SE
• Louise Edwards · Mississauga, CA
• Methvin Isaac · Toronto, CA
• Tom Stefanac · Mississauga, CA
• Abdelmalik Slassi · Mississauga, CA
• Don McLeod · Salt Lake City, US
• Tao Xin · Vaughan, CA

Key dates

• Filing date: Feb 18, 2005
• Grant date: Aug 18, 2009
• Expiry date: May 29, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention is directed to compounds of formula I:wherein X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, R1, R2, R3, R4, and n are as defined for formula I in the description. The invention also relates to processes for the preparation of the compounds and to new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and to the use of the compounds in therapy.