Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists

US7585881B2 · kind B2 · utility

Assignee

• ASTRAZENECA AB · SE

Inventors

• Louise Edwards · Mississauga, CA
• Methvin Isaac · Toronto, CA
• Martin Johansson · Helsingborg, SE
• Annika Kers · Malung, SE
• Johan Malmberg · Malung, SE
• Donald McLeod · Salt Lake City, US
• Alexander Mindis · Malung, SE
• Karin Staaf · Malung, SE
• Abdelmalik Slassi · Mississauga, CA
• Tomislav Stefanac · Toronto, CA
• Thomas Stormann · Salt Lake City, US
• David Wensbo · Malung, SE
• Tau Xin · Mississauga, CA
• Jalaj Arora · Mississauga, CA

Key dates

• Filing date: Feb 9, 2005
• Grant date: Sep 8, 2009
• Expiry date: Aug 16, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to new compounds of formula I,to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.