Tricyclic-bridged piperidinylidene derivatives as 8-opioid modulators

US7589103B2 · kind B2 · utility

Assignee

• Janssen Pharmaceutica NA · BE

Inventors

• John R. Carson · Norristown, US
• Ellen Codd · Blue Bell, US
• Christine M. Razler · Yardley, US
• Andrea Works · Morgantown, US
• Mark McDonnell · Lansdale, US
• James J. McNally · Souderton, US

Key dates

• Filing date: Jun 22, 2004
• Grant date: Sep 15, 2009
• Expiry date: Sep 19, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds, compositions and methods for treating various diseases and conditions, including pain. Such compounds are represented by Formula I as follows:wherein A, Z, Y, R1-R5 are defined herein.