(3,4-disubstituted)propanoic carboxylates as S1P (Edg) receptor agonists
US7605171B2 · kind B2 · utility
20Cited by
2References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 13, 2004 |
| Grant date | Oct 20, 2009 |
| Priority date | — |
| Expiry date | Jan 14, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention encompasses compounds of Formula I:as well as the pharmaceutically acceptable salts thereof. The compounds are S1P1/Edg1 receptor agonists and thus have immunosuppressive, anti-inflammatory and hemostatic activities by modulating leukocyte trafficking, sequestering lymphocytes in secondary lymphoid tissues, and enhancing vascular integrity. The invention is also directed to pharmaceutical compositions containing such compounds and methods of treatment or prevention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.