4-aminopyrimidine-5-one derivatives

US7615634B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• David Joseph Bartkovitz · Nutley, US
• Xin-Jie Chu · Livingston, US
• Qingjie Ding · Bound Brook, US
• Nan Jiang · Fairfield, US
• Allen John Lovey · North Caldwell, US
• John Anthony Moliterni · Bloomfield, US
• John G. Mullin, Jr. · Hawthorne, US
• Binh Thanh Vu · North Caldwell, US
• Peter Michael Wovkulich · Nutley, US

Key dates

• Filing date: Jun 20, 2006
• Grant date: Nov 10, 2009
• Expiry date: Jan 19, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel intermediate compounds are disclosed. These compounds are useful in the synthesis of 4-aminopyrimidine-5-one derivatives that inhibit cyclin-dependent kinases, in particular cyclin-dependent kinase 4 (Cdk4). The 4-aminopyrimidine-5-one derivatives and their pharmaceutically acceptable salts have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors.