Process for the preparation of (S)-4-fluoromethyl-dihydro-furan-2-one useful in the preparation of the DPP-IV inhibitor (S)-1 ((2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7, 11b-hexahydro-2H-pyrido[2,1-a] isoquinolin-3-yl)-4-fluoromethyl-pyrrolidin-2-one
US7619101B2 · kind B2 · utility
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21Claims
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Key dates
| Filing date | May 19, 2006 |
| Grant date | Nov 17, 2009 |
| Priority date | — |
| Expiry date | Jul 25, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to a process of the preparation of the novel intermediate (S)-4-fluoromethyl-dihydro-furan-2-one of the formulaand with its use for the manufacture of pyrido[2,1-a]isoquinoline derivatives of the formulawhich are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.