Methods of upmodulating an immune response with non-activating forms of B7-4
US7638492B2 · kind B2 · utility
64Cited by
3References
7Claims
0Family size
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Key dates
| Filing date | Aug 31, 2006 |
| Grant date | Dec 29, 2009 |
| Priority date | — |
| Expiry date | Aug 31, 2026 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention identifies PD-1 as a receptor for B7-4. B7-4 can inhibit immune cell activation upon binding to an inhibitory receptor on an immune cell. Accordingly, the invention provides agents for modulating PD-1, B7-4, and the interaction between B7-4 and PD-1 in order to modulate a costimulatory or an inhibitory signal in a immune cell resulting in modulation of the immune response.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.