Screening methods for the identification of inhibitors of human immunodeficiency virus (HIV) viral protein R (Vpr) binding to the adenine nucleotide translocator (ANT)
US7642051B2 · kind B2 · utility
2Cited by
2References
12Claims
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Key dates
| Filing date | Jul 8, 2005 |
| Grant date | Jan 5, 2010 |
| Priority date | — |
| Expiry date | Mar 13, 2026 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/20
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention is directed to the induction of mitochondrial membrane permeabilization via the physical and functional interaction of the HIV-1 Vpr protein with the mitochondrial inner membrane protein ANT (adenine nucleotide translocator, also called adenine nucleotide translocase or ADP/ATP carrier). Reagents and methods for inducing and/or inhibiting the binding of Vpr to ANT, mitochondrial membrane permeabilization, and apoptosis are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.