5-oxo-5,8-dihydro-pyrido-pyrimidine as inhibitors of c-fms kinase

US7642270B2 · kind B2 · utility

Assignee

• Janssen Pharmaceutica NA · BE

Inventors

• Mark R. Player · Phoenixville, US
• Hui Huang · Blue Bell, US
• Daniel A. Hutta · Montgomery, US
• Renee Louise Desjarlais · Saint Davids, US

Key dates

• Filing date: Sep 12, 2006
• Grant date: Jan 5, 2010
• Expiry date: Jan 18, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention addresses the current need for selective and potent protein tyrosine kinase inhibitors by providing potent inhibitors of c-fms kinase. The invention is directed to the novel compounds of Formula I:or a solvate, hydrate, tautomer or pharmaceutically acceptable salt thereof, wherein: W, A, Y, Z, R101 and R200 are described in the specification.