Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds

US7649015B2 · kind B2 · utility

Assignee

• Gilead Sciences, Inc. · US

Inventors

• Murty N. Arimili · Carrboro, US
• Xiaowu Chen · Hillsborough, US
• Maria Fardis · Redwood City, US
• Gong-Xin He · Cupertino, US
• Haolun Jin · Foster City, US
• Choung U. Kim · Redwood City, US
• William A. Lee · Palo Alto, US
• Kuei-Ying Lin · Fremont, US
• Hongtao Liu · Cupertino, US
• Richard L. Mackman · Millbrae, US
• Michael L. Mitchell · Union City, US
• Hyung-Jung Pyun · Fremont, US
• Mark Sparacino · معلمی نژاد, US
• Sundaramoorthi Swaminathan · Burlingame, US
• Jianying Wang · San Diego, US
• Matthew A. Williams · Foster City, US
• Lianhong Xu · Durham, US
• Zheng-Yu Yang · Chapel Hill, US
• Richard Hung Chiu Yu · San Francisco, US
• Jiancun Zhang · Dongguan, CN
• Lijun Zhang · Los Altos Hills, US

Key dates

• Filing date: Apr 25, 2003
• Grant date: Jan 19, 2010
• Expiry date: May 15, 2025

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.