Anti-Fc-gamma receptor antibodies, bispecific variants and uses therefor
US7662926B2 · kind B2 · utility
60Cited by
17References
39Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 18, 2007 |
| Grant date | Feb 16, 2010 |
| Priority date | — |
| Expiry date | Feb 8, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/76
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present application describes antibodies that selectively bind human FcγRIIB, with little or no binding to other human FcγRs, e.g., human FcγRIIA. The invention also provides isolated bispecific antibodies comprising an antibody that selectively binds FcγRIIB, and a second antibody that specifically binds an activating receptor. Various uses, including therapeutic uses, for those antibodies are also described, including administration with anti-tumor antibodies and methods of inhibiting immune responses and suppressing histamine release.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.