ADP-ribosyl acceptor hydrolase 3 (ARH3) polypeptides and methods of use

US7670806B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Joel Moss · Belconnen, AU
• Shunya Oka · Niigata, JP
• Jiro Kato · Rockville, US
• Jianfeng Zhu · Lo Wu, CN
• Atsushi Kasamatsu · Rockville, US

Key dates

• Filing date: Mar 12, 2008
• Grant date: Mar 2, 2010
• Expiry date: Mar 12, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y302/01143
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

This disclosure provides methods for catalyzing the release of ADP-ribose from poly(ADP-ribose) or O-acetyl-ADP-ribose. Also provided are methods for modifying DNA repair or chromatin structure by introducing into the cell an agent that modifies the activity of an ARH3 polypeptide, or variant or fragment thereof. Further provided are methods for screening molecules involved in the poly(ADP-ribosyl)ation of proteins or O-acetyl-ADP-ribose content, and method for treating disorders by altering activity of an ARH3 protein.