Macrocyclic tertiary amine beta-secretase inhibitors for the treatment of alzheimer's disease
US7678783B2 · kind B2 · utility
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3References
10Claims
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Key dates
| Filing date | Nov 14, 2005 |
| Grant date | Mar 16, 2010 |
| Priority date | — |
| Expiry date | Jan 24, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D498/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention is directed to macrocyclic tertiary amine compounds represented by general formula (I)which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.