Substituted benzimidazoles and imidazo-[4,5]-pyridines

US7687639B2 · kind B2 · utility

Assignee

• Janssen Pharmaceutica NA · BE

Inventors

• Michael K. Ameriks · San Diego, US
• Kristen L. Arienti · San Diego, US
• Frank Axe · Escondido, US
• J. Guy Breitenbucher · Escondido, US

Key dates

• Filing date: Jun 30, 2006
• Grant date: Mar 30, 2010
• Expiry date: Jun 30, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

2-Aryl substituted benzimidazoles and imidazo[4,5]pyridines are disclosed as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer.