Tetrazole compounds and their use as metabotropic glutamate receptor antagonists

US7691892B2 · kind B2 · utility

Assignee

• ASTRAZENECA AB · SE

Inventors

• Martin Johansson · Helsingborg, SE
• Alexander Minidis · Malung, SE
• Karin Staaf · Malung, SE
• David Wensbo · Malung, SE
• Donald McLeod · Salt Lake City, US
• Louise Edwards · Mississauga, CA
• Methvin Isaac · Toronto, CA
• Anne O'Brien · Schreiber, CA
• Abdelmalik Slassi · Mississauga, CA
• Tao Xin · Vaughan, CA
• Tomislav Stefanac · Toronto, CA

Key dates

• Filing date: Feb 18, 2005
• Grant date: Apr 6, 2010
• Expiry date: Apr 23, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to new compounds of formula I,wherein P, Q, X1, X2, X3, X4, R1, R2, m and p, are as defined as in formula I, or, salts, solvates or solvated salts thereof, processes for their preparation and new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds and to the use of said compounds in therapy.