Recombinant vector containing infectious human cytomegalovirus genome with preserved wild-type characteristics of clinical isolates
US7700350B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Jul 13, 2005 |
| Grant date | Apr 20, 2010 |
| Priority date | — |
| Expiry date | Dec 8, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2710/16161
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A recombinant vector containing infectious genome of human cytomegalovirus (HCMV) and being useful for the production of reconstituted HCMV virus retaining phenotypic characteristics of a clinical virus isolate including the ability to grow on endothelial cells and to induce microfusion is characterized in that it is obtainable by inserting DNA from a clinical isolate of HCMV virus into a bacterial cloning vehicle. Such vector can be used e.g., for production of reconstituted HCMV virus retaining the phenotypic characteristics of a parental clinical isolate and for studying genes and functions of genes of HCMV virus. A further aspect are mutant viruses and inter alia their use for studying aspects of infectivity of HCMV virus.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.