Selective inhibition of NF-κB activation by peptides designed to disrupt nemo oligomerization
US7700553B2 · kind B2 · utility
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28Claims
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Key dates
| Filing date | Sep 24, 2004 |
| Grant date | Apr 20, 2010 |
| Priority date | — |
| Expiry date | Apr 10, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/01
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to polypeptides that inhibit the NF-&kgr;B signaling pathway and polynucleotides encoding the same. The present invention further provides methods for the modulation of and/or treatment of inflammatory responses, oncogenesis, viral infection; the regulation of cell proliferation and apoptosis; and regulation of B or T lymphocytes in antigenic stimulation, by administering the polypeptides of the present invention to a subject in need thereof. Finally, the present invention provides a method of identifying polypeptides that modulate oligomerization of NEMO.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.