Acylated piperidine derivatives as melanocortin-4 receptor agonists

US7700778B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Mark Goulet · Westfield, US
• Ravi Nargund · East Brunswick Township, US
• Feroze Ujjainwalla · Hoboken, US
• Thomas F. Walsh · Stoneham, US
• Daniel Warner · Stoneham, US

Key dates

• Filing date: Sep 30, 2005
• Grant date: Apr 20, 2010
• Expiry date: Nov 15, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Certain novel 4-substituted N-acylated piperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.