Recovery of recombinant human parainfluenza virus type 1 (HPIV1) from cDNA and use of recombinant HPIV1 in immunogenic compositions and as vectors to elicit immune responses against PIV and other human pathogens
US7704509B2 · kind B2 · utility
18Cited by
3References
270Claims
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Key dates
| Filing date | Nov 21, 2002 |
| Grant date | Apr 27, 2010 |
| Priority date | — |
| Expiry date | May 27, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2760/18661
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Recombinant human parainfluenza virus type 1 (HPIV1) compostions, formulations and methods are provided. The recombinant HPIV1 viruses and HPIV1 chimeric and chimeric vector viruses provided according to the invention are infectious and attenuated in permissive mammalian subjects, including humans, and are useful in immunogenic composition s for eliciting an immune responses against one or more PIVs, against one or more non-PIV pathogens, or against a PIV and a non-PIV pathogen. Also provided are isolated polynucleotide molecules and vectors incorporating a recombinant HPIV1 genome or antigenome.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.