Protein kinase modulators and methods of use
US7704995B2 · kind B2 · utility
Assignee
Inventors
- Chris A. Buhr
- Tae-Gon Baik
- Sunghoon Ma
- Zerom Tesfai
- Longcheng Wang
- Erick Wang Co
- Sergey Epshteyn
- Abigail R. Kennedy
- Baili Chen
- Larisa Dubenko
- Neel K. Anand
- Tsze H. Tsang
- John M. Nuss
- Csaba J. Peto
- Kenneth D. Rice
- Mohamed Abdulkader Ibrahim
- Kevin Luke Schnepp
- Xian Shi
- James William Leahy
- Jeff Chen
- Lisa Esther Dalrymple
- Timothy Patrick Forsyth
- Tai Phat Huynh
- Grace Mann
- Larry W. Mann
- Craig Stacy Takeuchi
- Peter Lamb
- David Matthews
- Nicole E. Miller
Key dates
| Filing date | May 2, 2003 |
| Grant date | Apr 27, 2010 |
| Priority date | — |
| Expiry date | Feb 26, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D413/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion, and to pharmaceutical compositions containing such compounds. Even more specifically, the invention relates to compounds that inhibit, regulate and/or modulate kinases, particularly Checkpoint Kinases, even more particularly Checkpoint Kinase 1, or Chk1. Methods of therapeutically or prophylactically using the compounds and compositions to treat kinase-dependent diseases and conditions are also an aspect of the invention, and include methods of treating cancer, as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, by administering effective amounts of such compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.