Pyrimidine derivatives

US7709480B2 · kind B2 · utility

Assignees

• BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG · DE
• Boehringer Ingelheim Pharmaceuticals, Inc. · US

Inventors

• Georg Dahmann · Biberach an der Riß, DE
• Frank Himmelsbach · Mittelbiberach, DE
• Bernd Krist · Wien, AT
• Martin Lenter · Ulm, DE
• Alexander Pautsch · Ulm, DE
• Gisela Schapp · Zell am Harmersbach, DE
• Martin Steegmaier · Wien, AT
• Helmut Wittneben · Maselheim, DE
• Anthony S. Prokopowicz · Stormville, US
• Walter Spevak · Stockerau, AT
• Andreas Schoop · Overath, DE
• Steffen Steurer · Wien, AT

Key dates

• Filing date: Dec 21, 2005
• Grant date: May 4, 2010
• Expiry date: Mar 16, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to trisubstituted pyrimidines of formula (I)wherein0Ra to Re are defined as in claim 1, which are suitable for the treatment of illnesses characterized by excessive or abnormal cell proliferation, the use thereof for preparing a pharmaceutical composition with the abovementioned properties, and processes for the preparation thereof.