Separation of contaminants from Streptococcus pneumoniae polysaccharide by pH manipulation
US7718791B2 · kind B2 · utility
7Cited by
1References
14Claims
0Family size
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Key dates
| Filing date | Mar 31, 2006 |
| Grant date | May 18, 2010 |
| Priority date | — |
| Expiry date | Oct 2, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P19/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A process for reducing the protein content and preserving the capsular polysaccharide content in a complex cellular Streptococcus pneumoniae lysate broth prior to purification is described. Utilizing pH reduction after cellular lysis has resulted in a purified polysaccharide that consistently meets the protein specification, and higher recovery yields of polysaccharide during the purification process.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.